Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
説明 | 4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer |
In vitro | 4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death[1]. |
分子量 | 152.15 |
分子式 | C8H8O3 |
CAS No. | 3233-32-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (197.18 mM)
You can also refer to dose conversion for different animals. 詳細
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4-hydroxyphenyl acetate 3233-32-7 Immunology/Inflammation Nrf2 4hydroxyphenyl acetate 4-hydroxyphenyl Acetate 4 hydroxyphenyl acetate Inhibitor inhibitor inhibit