Powder: -20°C for 3 years | In solvent: -80°C for 1 year
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 30,000 | |||
5 mg | 在庫あり | ¥ 61,000 | |||
10 mg | 在庫あり | ¥ 100,500 | |||
25 mg | 在庫あり | ¥ 166,000 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 317,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . |
In vitro | API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines.?Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1.?API-1 treatment decreased the half-life of Mcl-1, whereas inhibition of the proteasome with MG132 rescued Mcl-1 reduction induced by API-1.?API-1 decreased Mcl-1 levels accompanied with a rapid increase in Mcl-1 phosphorylation (S159/T163).?Moreover, inhibition of GSK3 inhibited Mcl-1 phosphorylation and reduction induced by API-1 and antagonized the effect of API-1 on induction of apoptosis. |
別名 | NSC177223 |
分子量 | 337.29 |
分子式 | C13H15N5O6 |
CAS No. | 36707-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (66.71 mM)
You can also refer to dose conversion for different animals. 詳細
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API-1 36707-00-3 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt API 1 TRAIL PKB Inhibitor NSC-177223 API1 inhibit Akt/PKB inhibitor NSC177223 Protein kinase B NSC 177223 Apoptosis inhibitor