Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 62,500 | |||
100 mg | 在庫あり | ¥ 91,500 | |||
500 mg | 在庫あり | ¥ 215,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response. |
In vitro | SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling[1]. |
In vivo | SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30[2]. |
別名 | SMER 3 |
分子量 | 224.18 |
分子式 | C11H4N4O2 |
CAS No. | 67200-34-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (35.69 mM)
You can also refer to dose conversion for different animals. 詳細
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SMER3 67200-34-4 Others PROTAC Ligand for E3 Ligase SMER-3 Ubiquitin activating enzyme SCF E1/E2/E3 Enzyme anticancer MET Skp1 E1 activating enzyme ligase SMER 3 Inhibitor Cullin E2 conjugating enzyme ubiquitin Ubiquitin conjugating enzyme Ubiquitin ligase E3 ligating enzyme inhibit inhibitor