store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Arotinolol hydrochloride(Arotinolol HCl) is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 25,000 | |||
10 mg | 在庫あり | ¥ 37,500 | |||
25 mg | 在庫あり | ¥ 61,500 | |||
50 mg | 在庫あり | ¥ 90,000 | |||
100 mg | 在庫あり | ¥ 135,000 | |||
500 mg | 在庫あり | ¥ 287,000 |
説明 | Arotinolol hydrochloride(Arotinolol HCl) is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases. |
In vitro |
Arotinolol HCl shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol HCl displaces 125I-ICYP binding to 5HT1B-receptors with the pKi values of 7.97 and 8.16 respectively for β1 and β2 adrenergic receptors.[3] Arotinolol HCl shows its selectivity of β-adrenergic receptors, the result of Arotinolol HCl for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. The selective of β1 and β2 is equal.[3] |
In vivo | Arotinolol HCl (200 mg/kg; oral gavage; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mice.[3] |
別名 | Arotinolol HCl |
分子量 | 408 |
分子式 | C15H22ClN3O2S3 |
CAS No. | 68377-91-3 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (134.8 mM)
You can also refer to dose conversion for different animals. 詳細
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Arotinolol hydrochloride 68377-91-3 GPCR/G Protein Neuroscience Adrenergic Receptor 5-HT Receptor Arotinolol HCl Arotinolol Hydrochloride Inhibitor inhibitor inhibit