Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 28,500 | |||
5 mg | 在庫あり | ¥ 60,500 | |||
10 mg | 在庫あり | ¥ 90,500 | |||
25 mg | 在庫あり | ¥ 148,500 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 66,000 |
説明 | Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2]. |
ターゲット&IC50 | Cathepsin B:49 μM, Cathepsin L:12 μM |
In vitro | Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively. |
In vivo | Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling. |
植物由来 |
別名 | Asperglaucide |
分子量 | 444.52 |
分子式 | C27H28N2O4 |
CAS No. | 56121-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (123.73 mM)
You can also refer to dose conversion for different animals. 詳細
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Aurantiamide acetate 56121-42-7 Proteases/Proteasome Cysteine Protease Inhibitor cathepsin L Piper aurantiacum Aurantiamide Acetate Asperglaucide adjuvant-arthritic Cathepsin inhibit Aurantiamide inflammatory diseases inhibitor