Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,000 | |||
25 mg | 在庫あり | ¥ 29,500 | |||
50 mg | 在庫あり | ¥ 43,500 | |||
100 mg | 在庫あり | ¥ 64,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). |
ターゲット&IC50 | FBXO3:0.9 μg/mL |
In vivo | A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models. |
動物実験 | Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing |
分子量 | 394.51 |
分子式 | C26H26N4 |
CAS No. | 1507370-20-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.94 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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BC-1215 1507370-20-8 Others PROTAC Ligand for E3 Ligase Ligands for E3 Ligase E3 ligase-recruiting Moiety F-box protein 3 (Fbxo3) Inhibitor inhibit inflammation MLE cells BC1215 PBMC cells U937 cells TRAF BC 1215 inhibitor