Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
説明 | MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK. |
ターゲット&IC50 | NPM-ALK:11 nM(DC50)(SU-DHL-1 cells), ALK:33 nM(SU-DHL-1 cells), EML4-ALK:59 nM(DC50)(NCI-H2228 cells) |
In vitro | MS4078 effectively inhibits cancer cell proliferation. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1?cells with IC50 of 33 nM. MS4078 potently reduces the ALK fusion protein levels and inhibits the ALK auto-phosphorylation and down-steam STAT3 phosphorylation in both SU-DHL-1 and NCI-H2228?cells in a concentration-dependent manner. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. |
分子量 | 914.47 |
分子式 | C45H52ClN9O8S |
CAS No. | 2229036-62-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (53.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MS4078 2229036-62-6 Angiogenesis PROTAC Tyrosine Kinase/Adaptors ALK Ligand for E3 Ligase Anaplastic lymphoma kinase CD246 Inhibitor MS 4078 ALK tyrosine kinase receptor inhibit MS-4078 Anaplastic lymphoma kinase (ALK) PROTACs Cluster of differentiation 246 inhibitor