Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and improves hepatic insulin sensitivity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 17,500 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 57,000 | |||
50 mg | 在庫あり | ¥ 97,000 | |||
100 mg | 在庫あり | ¥ 144,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 19,500 |
説明 | BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and improves hepatic insulin sensitivity. |
In vivo | BC1618, whose potency in stimulating Ampk-dependent signaling greatly exceeds 5-aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) or metformin.?This compound increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.?Consistenting with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice[1]. |
別名 | 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- |
分子量 | 415.45 |
分子式 | C24H24F3NO2 |
CAS No. | 2222094-18-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (240.70 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BC1618 2222094-18-8 Autophagy Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling Ubiquitination E1/E2/E3 Enzyme Mitophagy AMPK Ubiquitin activating enzyme Mitochondrial Autophagy fission inhibit 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Inhibitor mTORC Ubiquitin ligase E1 activating enzyme AMP-activated protein kinase BC-1618 Ubiquitin conjugating enzyme Fbxo48 LPS metformin E3 ligating enzyme pAmpk pS6 mitochondrial BC 1618 insulin E2 conjugating enzyme inhibitor