Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 17,500 | |||
25 mg | 在庫あり | ¥ 37,000 | |||
50 mg | 在庫あり | ¥ 58,000 | |||
100 mg | 在庫あり | ¥ 97,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively). |
ターゲット&IC50 | 5-HT1A:7.2(pKi), 5-HT1B:6.9(pKi), 5-HT1F:9.25(pKi), 5-HT1E:8.7(pKi), 5-HT1D:7.2(pKi) |
キナーゼ試験 | In Vitro Radiometric PKD Kinase Assay: The radiometric kinase assay is carried out by coincubating 0.5 μCi of [γ-32P]ATP, 20 μM ATP, 50 ng of purified recombinant human PKD (PKD1, PKD2, and PKD3) or CAMKIIα proteins, and 2.5 μg of Syntide-2 in 50 μl of kinase buffer that contains 50 mM Tris-HCl, pH 7.5, 4 mM MgCl2, 10 mM β-mercaptoethanol. The reaction is carried out under conditions that the initial rate is within the linear kinetic range. The filter papers are then washed three times in 0.5% phosphoric acid, air-dried, and counted using a Beckman LS6500 multipurpose scintillation counter. |
別名 | BRL54443 |
分子量 | 230.31 |
分子式 | C14H18N2O |
CAS No. | 57477-39-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 2 mg/mL (8.68 mM)
DMSO: 43 mg/mL (186.7 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRL 54443 57477-39-1 GPCR/G Protein Neuroscience 5-HT Receptor 5-hydroxytryptamine Receptor Inhibitor BRL-54443 BRL54443 Serotonin Receptor inhibit inhibitor