Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 18,500 | |||
50 mg | 在庫あり | ¥ 31,000 | |||
100 mg | 在庫あり | ¥ 55,000 | |||
200 mg | 在庫あり | ¥ 68,500 | |||
500 mg | 在庫あり | ¥ 113,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. |
別名 | Naratriptan HCl, Amerge, Naramig, GR-85548A hydrochloride |
分子量 | 371.93 |
分子式 | C17H25N3O2S·HCl |
CAS No. | 143388-64-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (53.8 mM)
DMSO: 69 mg/mL (185.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Naratriptan hydrochloride 143388-64-1 GPCR/G Protein Neuroscience 5-HT Receptor Naratriptan Hydrochloride Naratriptan HCl Inhibitor GR-85548A Hydrochloride GR-85548A Naratriptan Amerge Naramig 5-hydroxytryptamine Receptor Serotonin Receptor inhibit GR-85548A hydrochloride inhibitor