Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery
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10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 11,000 | |||
50 mg | 在庫あり | ¥ 13,500 | |||
100 mg | 在庫あり | ¥ 20,500 | |||
200 mg | 在庫あり | ¥ 28,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery |
ターゲット&IC50 | [3H]-Initrendipine:0.21 nmol/l (Ki) |
In vivo | Barnidipine demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day[1]. Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure[2]. |
動物実験 | Forty-one patients (mean age 69 ± 17 years, 18 females) with previously diagnosed OSA (by reduced channel home-based polysomnography) who were not being treated with continuous positive airway pressure (CPAP) because of contraindications or because of patient intolerance or rejection were evaluated. Non-dipper status was defined as the presence of a nighttime fall in systolic blood pressure (BP) which was < 10% that of daytime systolic BP as observed in a previous ambulatory blood pressure (ABP) monitoring. OSA was defined according to the presence of 5 or more episodes per hour of apnoea, hypopnoea or arousal due to respiratory effort. The reproducibility of non-dipping status was confirmed through a second 24-h ABP monitoring performed at baseline. On top of the previous stable treatment regimen (which excluded calcium-channel blockers), a 10 mg dosing of barnidipine hydrochloride at bedtime was added to all subjects during a 12-week period[2]. |
別名 | YM-09730-5 hydrochloride, Mepirodipine (hydrochloride) |
分子量 | 528 |
分子式 | C27H30ClN3O6 |
CAS No. | 104757-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (473.48 mM)
You can also refer to dose conversion for different animals. 詳細
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Barnidipine hydrochloride 104757-53-1 Membrane transporter/Ion channel Metabolism Calcium Channel Mepirodipine Ca2+ channels inhibit Barnidipine YM-09730-5 hydrochloride Inhibitor Ca channels Barnidipine Hydrochloride Mepirodipine (hydrochloride) YM-09730-5 Hydrochloride inhibitor