Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 7,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 14,000 | |||
500 mg | 在庫あり | ¥ 22,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. |
In vivo | Under peak amyloid fibril formation conditions (pH 4.4), Flufenamic acid binds to wild-type transthyretin (KD1=30 nM, KD2=255 nM), V30M transthyretin (KD1=41 nM, KD2=320 nM), and L55P transthyretin (KD1=74 nM, KD2=682 nM) with high affinity and negative cooperativity (pH value 7.6), fully inhibiting fibril formation at a concentration of 10.8 μM. In Xenopus oocytes, Flufenamic acid reversibly suppresses ICl(Ca) in a dose-dependent manner, with an IC50 of 28 mM, without affecting the shape of the current-voltage curve in response to depolarizing voltage. Flufenamic acid inhibits the calcium-activated non-selective cation channels in the basolateral membrane of rat pancreatic exocrine cells activated by an inward-outward patch with an IC50 of 10 μM. The compound also inhibits currents activated by intracellular ADP-ribose in recombinant human TRPM2 (hTRPM2) channels and the CRI-G1 rat insulinoma cell line. Additionally, it reversibly inhibits (IC50=13.8 μM) DAP and phase discharge in rat suprachiasmatic neurons with similar kinetics, without significantly affecting membrane potential, spike threshold, or input resistance (P > 0.05), nor does it significantly affect the frequency and amplitude of spontaneous synaptic potentials. |
別名 | Arlef, Nichisedan, Achless |
分子量 | 281.23 |
分子式 | C14H10F3NO2 |
CAS No. | 530-78-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 28.1 mg/mL (100 mM)
DMSO: 28.1 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Flufenamic acid 530-78-9 Chromatin/Epigenetic Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience PI3K/Akt/mTOR signaling Potassium Channel Calcium Channel Chloride channel COX AMPK Parasite Arlef Cl? Channels Ca channels Nichisedan Ca2+ channels Cyclooxygenase Inhibitor inhibit Chloride Channel AMP-activated protein kinase KcsA Achless inhibitor