Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 在庫あり | ¥ 7,000 |
5 mg | 在庫あり | ¥ 11,000 |
10 mg | 在庫あり | ¥ 18,500 |
25 mg | 在庫あり | ¥ 34,500 |
50 mg | お問い合わせ | ¥ 62,500 |
100 mg | お問い合わせ | ¥ 105,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension. |
In vitro | Bimatoprost is an effective prostaglandin FP receptor agonist, capable of directly inducing a robust and rapid return of calcium ions to baseline levels. It directly activates FP prostaglandin receptors in rats, mice, and humans. |
In vivo | Bimatoprost displaces [3H] prostaglandin F (2alpha) binding to FP receptors with a Ki of 6.31 μM. It rapidly mobilizes intracellular calcium in 3T3 mouse fibroblasts expressing FP receptors (EC50: 2.2 μM) and human embryonic kidney cells with human FP receptors (EC50: 2.94 μM). Bimatoprost upregulates Cyr61 expression in feline irises and mildly stimulates aqueous humor outflow rate, increasing it by 13% during the day and 14% at night, while reducing tonographic outflow by 26%, thereby lowering intraocular pressure. |
別名 | AGN 192024 |
分子量 | 415.57 |
分子式 | C25H37NO4 |
CAS No. | 155206-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34 mg/mL (81.8 mM)
Ethanol: 77 mg/mL (185.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Bimatoprost 155206-00-1 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor AGN 192024 inhibit Inhibitor AGN-192024 AGN192024 inhibitor