Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).
説明 | Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP). |
ターゲット&IC50 | COX-2:7.45 nM (IC50), COX-1:5.56 nM (IC50) |
別名 | Bromfenac sodium, Bromfenac monosodium salt sesquihydrate |
分子量 | 383.17 |
分子式 | C15H12BrNO3·3/2H2O·Na |
CAS No. | 120638-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (32.62 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Bromfenac sodium hydrate 120638-55-3 Immunology/Inflammation Neuroscience COX inhibit Bromfenac monosodium sesquihydrate Bromfenac sodium Bromfenac monosodium salt sesquihydrate ocular inflammation HLEC-B3 Bromfenac sodium Hydrate Cyclooxygenase Inhibitor inhibitor