Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 7,000 | |||
10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 16,000 | |||
50 mg | 在庫あり | ¥ 20,500 | |||
100 mg | 在庫あり | ¥ 29,500 | |||
200 mg | 在庫あり | ¥ 44,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. |
ターゲット&IC50 | p110γ (Cell-free assay):89 nM, p110δ (Cell-free assay):2.5 nM |
In vitro | CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis[1]. |
別名 | (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, GS-1101, Idelalisib |
分子量 | 401.4 |
分子式 | C21H16FN7O |
CAS No. | 1146702-54-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (60.18 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CAL-101 1146702-54-6 PI3K/Akt/mTOR signaling PI3K CAL101 (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one CAL 101 GS-1101 GS1101 GS 1101 Idelalisib Inhibitor inhibitor inhibit