Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 36,500 | |||
5 mg | 在庫あり | ¥ 78,000 | |||
10 mg | 在庫あり | ¥ 123,500 | |||
25 mg | 在庫あり | ¥ 199,500 | |||
50 mg | 在庫あり | ¥ 273,500 | |||
100 mg | 在庫あり | ¥ 365,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 86,000 |
説明 | CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. |
In vitro | CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2]. |
In vivo | CC-90001 effectively mitigates lung fibrosis by significantly decreasing lung collagen metrics and lowering disease-induced α-SMA increases to nearly baseline levels in a house dust mite-induced lung fibrosis model. Moreover, when administered at a dosage of 3 mg/kg b.i.d., it hampers fibrosis development, evidenced by a notable reduction of 48% in collagen and 53% in α-smooth muscle actin (α-SMA) within a steatohepatitis model. |
分子量 | 321.42 |
分子式 | C16H27N5O2 |
CAS No. | 1403859-14-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (388.90 mM)
You can also refer to dose conversion for different animals. 詳細
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CC-90001 1403859-14-2 MAPK JNK CC90001 kinase IPF CC 90001 c-Jun idiopathic JNK1 Inhibitor N-terminal inhibit fibrosis pulmonary inhibitor