|
TP2134 |
c-JUN peptide
|
|
|
|
Peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21cip/waf and modulation of... |
|
T33467 |
MOMIPP
|
|
PI3K
|
|
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. |
|
T12189 |
NBDHEX
|
|
Apoptosis
,
Glutathione Peroxidase
,
Autophagy
|
|
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) . |
|
T9688 |
CC-90001
|
|
JNK
|
|
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. |
|
T9052 |
XL092
|
CL-092,JUN04542 |
VEGFR
,
c-Met/HGFR
,
TAM Receptor
|
|
XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders. |
|
T5097 |
Ezatiostat
|
TER199(free base),TLK199 |
Apoptosis
,
Glutathione Peroxidase
,
GST
|
|
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity. |
|
T9010 |
IMM-H007
|
|
Others
,
AMPK
|
|
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression |
|
T22776 |
Ezatiostat hydrochloride
|
TLK199 HCl,TER199 |
Glutathione Peroxidase
|
|
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydr... |
|
T2343 |
AS601245
|
|
JNK
|
|
AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties. |
|
T5416 |
T-5224
|
|
MMP
|
|
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. |
|
T5833 |
CC-401 Hydrochloride
|
CC401 HCl |
JNK
|
|
CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activity. |
|
T3598 |
JNK-IN-7
|
JNK inhibitor |
JNK
|
|
JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase. |
|
T16436 |
PBOX 6
|
PBOX-6 |
Apoptosis
|
|
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound with anticancer and antitumor activity that inhibits breast cancer cell growth in vitro and selectively induces apoptosis in leukemia cells via c-Jun NH2 terminal kin... |
|
T7677 |
JNK Inhibitor VIII
|
TCS JNK 6o |
JNK
|
|
JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively). |
|
T68060 |
Elgodipine
|
|
|
|
Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression ... |
|
TP1897L1 |
JIP-1 (153-163) acetate(438567-88-5 free base)
|
|
JNK
|
|
JIP-1 (153-163) acetate(438567-88-5 free base) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). JIP-1 (153-163) acetate(438567-88-5 free base) binds... |
|
T73457 |
DN-1289
|
|
DNA Alkylation
|
|
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK).DN-1289 signif... |
|
T3627 |
IQ-1S free acid
|
IQ-1,IQ-1S,IQ-1S (free acid) |
NF-κB
,
JNK
|
|
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can se... |
|
T8505 |
SC-236
|
Sc 236 |
Apoptosis
,
COX
,
PPAR
|
|
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). |
|
T69527 |
Erioflorin
|
|
|
|
Erioflorin is an ATP-competitive selective c-Jun N-terminal kinase (JNK) inhibitor. |
|
T81036 |
TAT-JIP
|
|
|
|
TAT-JIP effectively inhibits the phosphorylation of endogenous c-jun, which is activated by PHA–PMA [1]. |
|
T24830 |
SR-4326
|
|
|
|
SR-4326 is a c-Jun N-terminal Kinase 3 inhibitor. |
|
T13779 |
MPT0B392
|
|
Others
|
|
MPT0B392 is an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation. |
|
T29590 |
Acetoxycycloheximide
|
|
|
|
Acetoxycycloheximide induces cell surface TNF receptor 1. It also rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase. |
|
T11702 |
J30-8
|
|
Others
|
|
J30-8, a potent and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitor with an IC50 of 40 nM and 2500-fold isoform selectivity against JNK1α1 and JNK2α2, exhibits neuroprotective activity in vitro and shows pro... |
|
T16721 |
Ralimetinib
|
LY2228820 |
Others
|
|
Ralimetinib selectively inhibits phosphorylation of MK2 (Thr334) and has no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. Ralimetinib is an effective and selective, ATP-competitive inhibitor... |
|
TP1897 |
JIP-1(153-163)
|
JIP-1 (153-163) |
|
|
JIP-1(153-163) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). JIP-1(153-163) binds to JNK with affinity in the micromolar range and minimally inhi... |
|
T39586 |
Cantrixil
|
TRX-E-002-1 |
|
|
Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells... |
|
T36673 |
CC 401 dihydrochloride
|
|
|
|
High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase... |
|
T22343 |
HKB99
|
|
Others
|
|
HKB99 is a mutational inhibitor of phosphoglycerate mutase 1 (PGAM1).HKB99 increases oxidative stress, activates JNK/c-Jun, and inhibits AKT and ERK[1].HKB99 inhibits the formation of invasive pseudopods and raises the l... |
|
T79489 |
JNK-1-IN-2
|
|
JNK
|
|
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values of 112.9 nM and 33.2 nM, respectively. This compound effectively ... |
|
T72714 |
JNK3 inhibitor-3
|
|
JNK
|
|
JNK3 Inhibitor-3 (compound 15g) is a selective, blood-brain barrier permeable, and orally active inhibitor of c-Jun N-terminal kinase 3 (JNK3) with IC50 values of 147.8 nM, 44.0 nM, and 4.1 nM against JNK1, JNK2, and JNK... |
|
T35943 |
15(S)-HpETE
|
|
|
|
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by ... |
|
T37969 |
12(S)-HpETE
|
|
|
|
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the sy... |
|
T37458 |
C18 Phytoceramide (t18:0/18:0)
|
|
|
|
C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine b... |
|
T36346 |
Ac-VEID-AMC (ammonium acetate salt)
|
|
|
|
Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase acti... |
|
T38269 |
Purfalcamine
|
|
|
|
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala... |
|
T35536 |
Tpl2 Kinase Inhibitor (hydrochloride)
|
|
|
|
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kina... |
