Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
説明 | BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression. |
In vitro | The proliferation and cell viability of all cell lines were inhibited by treatment with 5?μM BIA.The IC50 values at 3 days were 1.7?±?0.1?μM for HT1080, 2.6?±?0.4?μM for MCF cells, 2.6?±?0.5?μM for MDA-MB-231 cells, and 2.4?±?0.4?μM for SKBR3 cells. Moreover, HT1080 cells stably overexpressing TMBIM6 showed high sensitivity to BIA[1].BIA decreases the binding between TMBIM6 and mTORC2, we performed a gel filtration assay in TMBIM6-overexpressing HT1080 cells after treatment with BIA during 24?h[1]. |
分子量 | 268.27 |
分子式 | C15H12N2O3 |
CAS No. | 134271-74-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (242.29 mM)
You can also refer to dose conversion for different animals. 詳細
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CDC25B-IN-2 134271-74-2 Metabolism PI3K/Akt/mTOR signaling Phosphatase mTOR Inhibitor CDC-25B-IN-2 CDC25BIN2 CDC25B IN 2 inhibit inhibitor