Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 15,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM). |
ターゲット&IC50 | CK2:0.25 μM (ki), CK2:0.5 μM, DYRK1A:11.9 μM (ki), HIPK2:15.25 μM (ki), Pim1:8.65 μM (ki), Apoptosis:, ERK8:0.5 μM |
In vitro | In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours) treatment displays cytotoxic activity[1]. |
別名 | TMCB |
分子量 | 534.82 |
分子式 | C11H9Br4N3O2 |
CAS No. | 1085822-09-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL (29.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CK2/ERK8-IN-1 1085822-09-8 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling MAPK Metabolism Stem Cells Tyrosine Kinase/Adaptors DYRK Casein Kinase Pim ERK TMCB Inhibitor inhibitor inhibit