Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
2 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 33,000 | |||
25 mg | 在庫あり | ¥ 68,500 | |||
50 mg | 在庫あり | ¥ 112,500 | |||
100 mg | 在庫あり | ¥ 166,000 |
説明 | CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity. |
ターゲット&IC50 | KCC2:(EC50)616 nM |
分子量 | 307.34 |
分子式 | C14H14FN3O2S |
CAS No. | 1181081-71-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17.86 mg/mL (58.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CLP257 1181081-71-9 Membrane transporter/Ion channel Potassium Channel Inhibitor post-translationally hypersensitivity plasma neuropathic antihyperalgesic CLP-257 CLP 257 membrane KcsA mechanical sensitivity KCC2 inhibit inhibitor