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T9685 |
DS-1971a
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Sodium Channel
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DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. |
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T4563 |
Thonzylamine
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neohetramine |
Histamine Receptor
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Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhin... |
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T5491 |
GSK3179106
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c-RET
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GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
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T14984 |
CLP257
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Potassium Channel
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CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al... |
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T14127 |
Adenosine A1 receptor activator T62
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Adenosine Receptor
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Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve... |
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T1824 |
TGR5 Receptor Agonist
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GPCR19
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TGR5 is a potent TGR5(GPCR19) agonist. |
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T21472 |
Dimethindene maleate
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UNII-6LL60J9E0O,SU 6518,SU-6518 |
Histamine Receptor
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Dimethindene maleate (SU 6518) is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis. |
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T124635 |
Cyclo(L-Pro-L-Ile)
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Cyclo(L-Pro-L-Ile) is a bis-ketopiperazine from Bacillus thuringiensis that induces a moderate hypersensitivity reaction and can be used to study pine wilt. |
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T15192 |
Eact
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Chloride channel
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Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity. |
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T16448 |
PD173212
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Calcium Channel
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PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice. |
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T77340L |
AB21 HCl
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Sigma receptor
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AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity. |
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T16240 |
N,N'-Diacetyl-L-cystine
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(Ac-Cys-OH)2,DiNAC |
Others
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N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL... |
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T3627 |
IQ-1S free acid
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IQ-1,IQ-1S,IQ-1S (free acid) |
NF-κB
,
JNK
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IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can se... |
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T15096 |
Delgocitinib
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JTE-052,Corectim（Delgocitinib） |
Tyrosine Kinases
,
JAK
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Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune d... |
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T19839 |
Oxatomide
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Oxatomida |
P2X Receptor
,
Calcium Channel
,
5-HT Receptor
,
Histamine Receptor
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Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2... |
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T24771 |
SCH-336
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SCH336,SCH 336 |
Cannabinoid Receptor
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SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 red... |
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T15167 |
Draflazine
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R-75231 |
Others
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Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carra... |
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T71716 |
Nav1.1-IN-B
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Nav1.1-IN-B is a selective NaV1.1 inhibitor which reduces visceral hypersensitivity. |
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T69431 |
A-420983
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A-420983 is a novel potent Lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection. |
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T71310 |
DS 4574
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DS 4574 is a peptidoleukotriene receptor antagonist used in treatment of hypersensitivity. |
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T71938 |
MNF
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MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS). |
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T71308 |
DSP-6952
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DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction. |
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T80501 |
Myr-TAT-CBD3
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Calcium Channel
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Myr-TAT-CBD3, a CRMP2-CaV2.2 interaction inhibitor, has been shown to significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity in a rat model of postoperative pain, making... |
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T69950 |
Delgocitinib EtOH
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|
|
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Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic ... |
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T31126 |
CX-659S
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CX659S,UNII-YG2F04AVMQ,CX 659S |
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CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens ... |
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T70340 |
JHU-58
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JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in subs... |
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T78000 |
OVA Peptide (323-339)
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OVA Peptide (323-339) constitutes a T and B cell epitope derived from Ovalbumin (Ova), crucial for eliciting immediate hypersensitivity reactions in BALB/c mice. |
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T78916 |
AB21 oxalate
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Sigma receptor
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AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces mechanical hypersensitivity [1]. |
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T36478 |
BI-6901
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CCR
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BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner. |
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T71053 |
AHR-5333 mandelate
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AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to in... |
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TP1339 |
OVA Peptide 323-339
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OVA Peptide (323-339) represents a T and B cell epitope of Ovalbumin (Ova), which play an important role in the development and development of immediate hypersensitivity in BALB/c mice. |
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T60289 |
Pemirolast
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|
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Pemirolast is an orally active antiallergic agent. Pemirolast attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides, that can be used for bronchial asthma and conjunc... |
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T83213 |
AC-099
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AC-099 (compound 3) serves as a selective full agonist at NPFF2R (EC50 = 1189 nM) and a partial agonist at NPFF1R (EC50 = 2370 nM). It has been shown to mitigate hypersensitivity induced by spinal nerve ligation in rats ... |
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T73433 |
MS47134
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|
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MS47134, a selective and potent MRGPRX4 agonist, exhibits an EC50 of 149 nM and holds potential for researching pain, itch, and mast cell-mediated hypersensitivity. |
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T38326 |
Cromolyn (sodium salt hydrate)
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|
|
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Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across ... |
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T67212 |
Ligustrazine HCl
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|
|
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Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithromb... |
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T21916 |
TC-SP 14
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TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its ... |
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T78923 |
DDO-8926
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Epigenetic Reader Domain
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DDO-8926 is a potent, selective BET inhibitor shown to markedly diminish mechanical hypersensitivity in neuropathic pain research by suppressing pro-inflammatory cytokine expression and decreasing neuronal excitability [... |
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T35461 |
δ14-Triamcinolone acetonide
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|
|
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δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sen... |
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T37167 |
Reduced Haloperidol
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Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4... |
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T37620 |
Leukotriene C4 methyl ester
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|
|
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Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met... |
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T31657 |
Epothilone F
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|
|
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Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F ... |
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T38128 |
Leukotriene D4
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Leukotriene D4 MaxSpec® Standard,LTD4 |
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Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4... |
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T36851 |
Peptide5
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|
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Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll ... |
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T83731 |
Tat-CBD3 TFA
|
|
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Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
