|
T16164 |
MY-5445
|
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE
|
|
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM). |
|
T22360 |
MDR-652
|
|
TRP/TRPV Channel
|
|
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... |
|
T14984 |
CLP257
|
|
Potassium Channel
|
|
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al... |
|
T8975 |
PSB-SB-487
|
|
Cannabinoid Receptor
|
|
PSB-SB-487 is antagonist of GPR55. |
|
T4298 |
JNJ-47965567
|
JNJ-479655 |
P2X Receptor
|
|
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). |
|
T2024 |
A-803467
|
A 803467,A803467 |
Sodium Channel
|
|
A-803467 is a selective NaV1.8 channel blocker. |
|
T14127 |
Adenosine A1 receptor activator T62
|
|
Adenosine Receptor
|
|
Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve... |
|
T16014 |
Mavatrep
|
JNJ-39439335 |
TRP/TRPV Channel
|
|
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. |
|
TQ0002 |
A-317491
|
ABT 202 |
P2X Receptor
|
|
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. |
|
T0386L |
Ropivacaine
|
LEA-103 HCl |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group. |
|
T7748 |
Dermorphin TFA
|
|
Others
,
Opioid Receptor
|
|
Dermorphin TFA is a new class of opioids-like peptides |
|
T21980 |
PD 198306
|
|
MEK
|
|
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. |
|
T7416 |
WS-12
|
|
TRP/TRPV Channel
|
|
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM) |
|
T0386 |
Ropivacaine hydrochloride
|
Ropivacaine monohydrochloride |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. |
|
T4142 |
PCC0208009
|
IDO inhibitor 1,DO-IN-2,IDO-IN-2 |
Indoleamine 2,3-Dioxygenase (IDO)
|
|
PCC0208009 (IDO-IN-2) is an IDO inhibitor. |
|
T23008L |
MMPIP hydrochloride
|
MMPIP hydrochloride (479077-02-6 Free base) |
GluR
|
|
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
|
T8579 |
Nav1.8-IN-1
|
5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208 |
Sodium Channel
|
|
Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8 |
|
T8333 |
Aurintricarboxylic acid
|
ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
|
T7705 |
GW 405833
|
L-768242 |
Cannabinoid Receptor
|
|
GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective |
|
T29112 |
VPC171
|
VPC 171,VPC-171 |
Adenosine Receptor
|
|
VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM). |
|
T3280 |
Clodronate disodium tetrahydrate
|
clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium |
IL Receptor
,
TNF
|
|
Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification. |
|
T0678 |
Amitriptyline hydrochloride
|
Amitriptyline HCl,Tryptizol,Domical,Annoyltin |
Trk receptor
,
Sigma receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
|
T6645 |
Ropivacaine hydrochloride monohydrate
|
Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. |
|
T7404 |
Dermorphin
|
|
Opioid Receptor
|
|
Dermorphin is agonist of μ-opioid receptor (MOR) agonist. |
|
T28059 |
MK-4409
|
MK4409,MK 4409 |
|
|
MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, is being investigated for the treatment of inflammatory and neuropathic pain. |
|
T27178 |
Dimiracetam
|
ISF4185,ISF-4185,NT11624,NT-11624,BND11624,BND-11624 |
|
|
Dimiracetam, a NMDA-receptor antagonist, is used potentially for the treatment of neuropathic pain. |
|
T16514 |
PF 04531083
|
|
Others
,
Sodium Channel
|
|
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies. |
|
T6507 |
Gabapentin hydrochloride
|
Neurontin HCl,Gabapentin HCl |
Calcium Channel
,
GABA Receptor
|
|
Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain. |
|
T1007 |
Nanofin
|
Lupetidine,Lupetidin,2,6-Lupetidine,2,6-Dimethylpiperidine,Naniopinum |
AChR
|
|
Nanofin (Lupetidine) is a neuropathic blocker, with antihypertensive effect. |
|
T12910 |
Sigma-1 receptor antagonist 1
|
|
Sigma receptor
|
|
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie... |
|
T10290L |
Alpertine HCl
|
Win 31665 HCl,Alpertine HCl（27076-46-6 Free base） |
Others
|
|
Alpertine HCl is a small molecule compound with anti-neuropathic properties. |
|
T22240 |
Amitriptyline
|
|
Sigma receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
|
T0598 |
Iminostilbene
|
Dibenzazepine |
Others
|
|
Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. |
|
T27404 |
GAT107
|
GAT 107,GAT-107 |
AChR
|
|
GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain. |
|
T10190 |
7-BIA
|
|
Phosphatase
|
|
|
|
T20494L |
Acetyl tetrapeptide-15 Acetate
|
Skinasensyl Acetate,Acetyl tetrapeptide-15 Acetate (928007-64-1 Free base) |
|
|
Acetyl tetrapeptide-15 Acetate (Skinasensyl Acetate), a synthetic peptide used in cosmetic products for sensitive skin, is an endomorphin-2 derivative that extends the range of neuronal excitability thresholds in the μ-o... |
|
T5698 |
TRPM8 antagonist 2
|
|
TRP/TRPV Channel
|
|
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. |
|
T77333L |
(Iso)-BMT-124110 Formate
|
(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base） |
AAK1 (AP2 associated kinase 1)
|
|
(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease. |
|
T3699 |
Bay 59-3074
|
|
Cannabinoid Receptor
|
|
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic and antiallodynic properties. |
|
T5385 |
Radiprodil
|
RGH-896 |
NMDAR
,
iGluR
|
|
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
|
T31208 |
Dasolampanel
|
NGX-426,NGX 426,NGX426 |
GluR
,
iGluR
|
|
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine. |
|
T11724 |
JNJ-42226314
|
|
Lipase
|
|
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ... |
|
T7349 |
Ralfinamide
|
Priralfinamide,FCE-26742A |
Sodium Channel
|
|
Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions. |
|
T79500L |
KSK94 FA
|
KSK94 FA(2566716-07-0 Free base) |
Histamine Receptor
|
|
KSK94 FA is a potent histamine H3 receptor antagonist that inhibits H3 receptors and is used in the study of neuropathic pain and obesity. |
|
T34308 |
Rezatomidine
|
AGN-203818,AGN203818,AGN 203818 |
Adrenergic Receptor
|
|
Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain. |
|
TP1559L |
Ziconotide Acetate (107452-89-1 free base)
|
Prialt,Ziconotide Acetate |
Calcium Channel
|
|
Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan... |
|
T9955 |
EX-A5758
|
|
NOS
|
|
EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. |
|
T12051 |
MIV-247
|
|
Cysteine Protease
|
|
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathi... |
|
T77606 |
WAY-311610
|
|
Dehydrogenase
|
|
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia. |
|
T5815 |
MJN110
|
Cravatt Reagent |
Lipase
|
|
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. |
