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T9685 |
DS-1971a
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Sodium Channel
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DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. |
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T14984 |
CLP257
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Potassium Channel
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CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al... |
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T15050 |
Danicamtiv
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MYK-491,SAR 440181 |
Myosin
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Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency. |
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T11941 |
Manitimus
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FK778 |
Dehydrogenase
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Manitimus (FK778) is an inhibitor of dehydroorotate dehydrogenase and an immunosuppressant with immunosuppressive and antiproliferative activity, prevents vascular remodeling after mechanical endothelial injury, and can ... |
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T21380 |
Pravadoline
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WIN 48098-6,WIN48098-6,WIN-48098-6 |
Cannabinoid Receptor
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Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan... |
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TP1309 |
Gastric mucin
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Antibacterial
,
Antibiotic
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Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. |
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T11244 |
Etimizol
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Ethymisol,Ethimizole,Ethymisole |
Others
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Etimizol (Ethimizole) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The positive effect of Etimizol on ... |
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T0156 |
Rocuronium bromide
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ORG 9426,ORG 9426 (Bromide) |
AChR
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Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeleta... |
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T28270 |
Osemozotan HCl
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MCI-242,MN-305,Osemozotan hydrochloride,MKC-242,MKC242,MCI242 |
5-HT Receptor
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Osemozotan HCl (Osemozotan hydrochloride) is a novel and selective 5-HT1A receptor agonist that reduces methamphetamine-induced c-Fos expression in the medial prefrontal cortex and striatum.Osemozotan HCl is used in the ... |
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T77340L |
AB21 HCl
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Sigma receptor
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AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity. |
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T12051 |
MIV-247
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Cysteine Protease
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MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathi... |
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TP1933 |
R715 TFA(185052-09-9 free base)
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R 715 |
Bradykinin Receptor
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R715 TFA(185052-09-9 free base) is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Me... |
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TP1220L |
ANP(1-28) Acetate (human, porcine)
|
Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate |
Endothelin Receptor
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Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compou... |
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T21543 |
AP 18
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TRP/TRPV Channel
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T14198 |
ALX-1393
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GlyT
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ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu... |
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TP1904L |
FSLLRY-NH2 TFA(245329-02-6 free base)
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Protease-activated Receptor
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FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso... |
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T41005 |
PA-8
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PACAP
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PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vp... |
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T11700 |
J-2156
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Others
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The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type... |
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T80500 |
Jingzhaotoxin-X
|
JZTX-X |
Potassium Channel
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Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1]. |
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T15167 |
Draflazine
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R-75231 |
Others
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Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carra... |
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T23642L |
ADR-851 HCl
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Adr-851,Adr 851,Adr851 |
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ADR-851 HCl is an HT3 receptor antagonist. It works against mechanical, acute thermal, and formalin-induced inflammatory pain. |
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T40173 |
Spiropyran hexyl methacrylate
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Spiropyran hexyl methacrylate is a compound utilized to create a spiropyran-based polymeric hydrogel, specifically to enable light-activated mechanical actuation. |
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T25637 |
Laudexium methylsulfate
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Laudexium,Laudolissin methosulphate |
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Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during ... |
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TQ0002L |
A-317491 sodium
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A-317491,A 317491,A317491 |
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A-317491 is an effective selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which reverses inflammatory mechanical hyperalgesia and relieves chronic inflammation and neuropathic pain in rats by acting on p... |
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T70340 |
JHU-58
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JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in subs... |
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T78916 |
AB21 oxalate
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Sigma receptor
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AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively. It effectively reduces mechanical hypersensitivity [1]. |
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T81231 |
S6 peptide
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S6 peptide, a lamin kinase of potential importance, plays a role in the induction of cardiac hypertrophy following mechanical loading and can be activated by various growth factors [1]. |
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T61091 |
P38-α MAPK-IN-4
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p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM. It effectively and swiftly mitigates the onset of mechanical allodynia (MA) in vivo [1]. |
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TP1220 |
Carperitide
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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine |
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Carperitide, a 28-amino acid hormone known as Atrial Natriuretic Peptide (ANP) (1-28), is naturally synthesized and released by the human heart in reaction to cardiac injury and mechanical stretch. This compound effectiv... |
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T25636 |
Laudexium
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Laudexium ion,Laudexium cation |
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Laudexium is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubatio... |
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T64113 |
J-2156 TFA
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J-2156 TFA is a selective and potent growth inhibitor receptor type 4 (SST4) agonist that acts on the human SST4 receptor (IC50: 0.05 nM) and rat SST4 receptor (IC50: 0.07 nM). J-2156 TFA exhibited anti-inflammatory acti... |
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TP1904 |
FSLLRY-NH2
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|
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Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduce... |
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T71559 |
Melanotan II acetate
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|
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Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases... |
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T78923 |
DDO-8926
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Epigenetic Reader Domain
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DDO-8926 is a potent, selective BET inhibitor shown to markedly diminish mechanical hypersensitivity in neuropathic pain research by suppressing pro-inflammatory cytokine expression and decreasing neuronal excitability [... |
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T81664 |
NMB-1
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NMB-1, a conopeptide analogue, selectively inhibits sustained mechanically activated currents in sensory neurons with an IC50 of 1 μM, attenuating mechanical pain. It is utilized in research pertaining to hearing and pre... |
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T67212 |
Ligustrazine HCl
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|
|
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Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithromb... |
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T80446 |
ω-Conotoxin FVIA
|
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Calcium Channel
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ω-Conotoxin FVIA is an inhibitor of N-type Ca²⁺ channels (Caᵥ2.2), shown to alleviate mechanical and thermal pain abnormalities in a rat model of caudal nerve injury. This compound has potential utility in the research o... |
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T35461 |
δ14-Triamcinolone acetonide
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|
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δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sen... |
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T37167 |
Reduced Haloperidol
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|
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Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4... |
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T71955 |
C3001a
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|
|
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C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous sy... |
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T38147 |
(S)-AM1241
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(S)-AM1241 |
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(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human,... |
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T38030 |
(R)-AM1241
|
(R)-AM1241 |
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(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts... |
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T76254L |
CD31 TFA
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CD31 TFA, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), functions as the specific receptor for Clostridium perfringens beta-Toxin (CPB) in endothelial cells. It is recognized as an ER-MP12 antige... |
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T38109 |
Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
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Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the G... |
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T76254 |
CD31
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|
|
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CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a receptor on endothelial cells for clostridium perfringens beta-Toxin (CPB). It also functions as an ER-MP12 antigen and connects mechanica... |
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T35597 |
Neuromedin U-23 (rat) (trifluoroacetate salt)
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|
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Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.1... |
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T83701 |
TRPV1-Tat TFA
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Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat |
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TRPV1-Tat, a peptide antagonist targeting transient receptor potential vanilloid 1 (TRPV1), is composed of amino acids 736-745 derived from TRPV1's A-kinase anchor protein (AKAP)-binding domain, combined with the HIV Tat... |
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T83728 |
Tat-AKAP79 (326-336) TFA
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Tat-A-kinase Anchor Protein 79 (326-336) |
|
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Tat-AKAP79 (326-336) is a peptide that links the HIV-1 Tat protein transduction domain with an 11-amino acid sequence from A-kinase anchor protein 79 (AKAP79). This compound effectively inhibits the activation-induced se... |
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T36851 |
Peptide5
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|
|
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Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll ... |
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T83674 |
K 41498 TFA
|
|
|
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K 41498 is a selective peptide antagonist targeting both corticotropin-releasing factor receptor 2α (CRF2α) and CRF2β, demonstrating high affinity with Kis of 0.66 and 0.62 nM, respectively, in HEK293 cells expressing th... |
