Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
説明 | CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431. |
ターゲット&IC50 | ACC2:61 nM, ACC1:53 nM |
キナーゼ試験 | Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit. |
別名 | CP 640186 HCl |
分子量 | 522.08 |
分子式 | C30H36ClN3O3 |
CAS No. | 591778-70-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (95.77 mM)
You can also refer to dose conversion for different animals. 詳細
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CP-640186 hydrochloride 591778-70-0 Metabolism Acetyl-CoA Carboxylase ACC, Acetyl Coenzyme A Carboxylase CP 640186 muscle fatty acid oxidation CP 640186 Hydrochloride CP640186 hydrochloride C2C12 HepG2 H460 CP640186 human fibroblasts inhibit CP-640186 Hydrochloride CP640186 Hydrochloride CP 640186 HCl muscle strips CP-640186 Inhibitor CP 640186 hydrochloride inhibitor