Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
説明 | CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. |
ターゲット&IC50 | CBP:0.03 μM, EP300:0.051 μM |
In vitro | CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1]. |
キナーゼ試験 | Ki Determination: Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis. |
細胞研究 | AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 μM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference) |
別名 | CPI 637 |
分子量 | 386.45 |
分子式 | C22H22N6O |
CAS No. | 1884712-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26 mg/mL (67.3 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CPI-637 1884712-47-3 Chromatin/Epigenetic Histone Acetyltransferase Epigenetic Reader Domain Inhibitor inhibit HAT HATs CPI637 CPI 637 inhibitor