Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 9,000 | |||
100 mg | 在庫あり | ¥ 12,500 | |||
200 mg | 在庫あり | ¥ 15,500 | |||
500 mg | 在庫あり | ¥ 33,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent. |
In vitro | Clonidine, at concentrations of 0.01, 0.1, or 1 μM, significantly elevates CGRP (α and β) mRNA expression in endothelial cells in a dose-dependent manner. Additionally, a 24-hour treatment with 1 μM clonidine notably augments NO levels in these cells. This indicates that the NO pathway plays a crucial role in modulating the clonidine-induced CGRP production[2]. |
In vivo | Administered intraperitoneally at a dose of 50 μg/kg, clonidine markedly reduces rat body temperature, peaking at 1 hour and persisting for 3 hours; this effect is notably counteracted by a pre-administration of phentolamine into the cerebral ventricles[1]. Additionally, clonidine (0.003-0.05 mg/kg, i.p.) effectively inhibits PCP-induced dopamine release in the prefrontal cortex, an effect that is blocked by the alpha-2A receptor antagonist BRL-44408[3]. In normotensive rats treated with DMSO, clonidine (0.6 μg intracisternally) does not alter blood pressure, but following central adenosine A1R inhibition with DPCPX, it significantly lowers blood pressure. Conversely, in DMSO-treated aortic-banded rats, clonidine prominently decreases blood pressure, a response that remains unchanged after DPCPX pretreatment. Additionally, in SO rats with central A1R blockage, clonidine not only reduces blood pressure but also significantly elevates pERK1/2 levels in the RVLM, an effect not observed in DMSO-pretreated SO rats. Similarly, clonidine boosts RVLM pERK1/2 levels in vehicle-treated aortic-banded rats, unaffected by DPCPX[4]. |
別名 | Clonidine HCl, Catapres |
分子量 | 266.55 |
分子式 | C9H10Cl3N3 |
CAS No. | 4205-91-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 26.7 mg/mL (100 mM)
DMSO: 20 mg/mL (75 mM)
You can also refer to dose conversion for different animals. 詳細
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Clonidine hydrochloride 4205-91-8 GPCR/G Protein Neuroscience Adrenergic Receptor Clonidine HCl inhibit Clonidine Clonidine Hydrochloride Inhibitor Catapres Beta Receptor inhibitor