Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. 3. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. 4. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 22,000 | |||
10 mg | 在庫あり | ¥ 38,000 | |||
25 mg | 在庫あり | ¥ 73,500 | |||
50 mg | 在庫あり | ¥ 110,000 | |||
100 mg | 在庫あり | ¥ 158,000 | |||
500 mg | 在庫あり | ¥ 326,000 |
説明 | 1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. 3. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. 4. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D. |
植物由来 |
分子量 | 339.39 |
分子式 | C20H21NO4 |
CAS No. | 25127-29-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62 mg/mL(182.7 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
You can also refer to dose conversion for different animals. 詳細
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Crebanine 25127-29-1 Apoptosis Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Akt PKB inhibit Protein kinase B Inhibitor inhibitor