Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 38,500 | |||
25 mg | 在庫あり | ¥ 77,500 | |||
50 mg | 在庫あり | ¥ 137,000 | |||
100 mg | 在庫あり | ¥ 183,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,500 |
説明 | Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells. |
In vitro | Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3] |
In vivo | In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels. [2] |
細胞研究 | For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference) |
植物由来 |
別名 | Cuc B, DATISCACIN, Amarine |
分子量 | 558.7 |
分子式 | C32H46O8 |
CAS No. | 6199-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91 mg/mL(162.9 mM)
Chloroform, Dichloromethane, Ethyl Acetate: Soluble
Ethanol: 50 mg/mL (89.49 mM)
You can also refer to dose conversion for different animals. 詳細
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Cucurbitacin B 6199-67-3 Angiogenesis Apoptosis Autophagy Chromatin/Epigenetic Cytoskeletal Signaling JAK/STAT signaling Metabolism PI3K/Akt/mTOR signaling Stem Cells PTEN Integrin Endogenous Metabolite STAT HIF Inhibitor Cuc B inhibit DATISCACIN Amarine inhibitor