Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
説明 | DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9. |
In vitro | DBPR108 displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. |
In vivo | DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. The in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. |
分子量 | 324.39 |
分子式 | C16H25FN4O2 |
CAS No. | 1186426-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥ 25 mg/mL (77.07 mM)
You can also refer to dose conversion for different animals. 詳細
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DBPR108 1186426-66-3 Proteases/Proteasome Ubiquitination Proteasome DPP-4 Inhibitor DBPR-108 inhibit DPP DBPR 108 Dipeptidyl Peptidase inhibitor