Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,500 | |||
25 mg | 在庫あり | ¥ 14,000 | |||
50 mg | 在庫あり | ¥ 19,500 | |||
100 mg | 在庫あり | ¥ 23,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. |
In vitro | The compound Sodium Danshensu was administered in two different methods to assess its toxicity. When orally administered to mice, the LD50 was determined to be 2356.33 mg/kg; conversely, when injected intravenously into rats, the LD50 was found to exceed 1500 mg/kg. |
In vivo | Danshensu is an effective free radical scavenger and antioxidant. Sodium danshensu exerts a biphasic action on vascular tension, where a low dose may induce minor contractions through a momentary increase in Ca2+ influx, while higher doses predominantly cause significant vasodilation by facilitating the opening of non-selective K+ channels and small-conductance Ca2+-sensitive K+ channels in vascular smooth muscle cells. Additionally, sodium danshensu inhibits vasoconstriction induced by norepinephrine and CaCl2 in a free Ca(2+) medium. Pre-treatment with sodium danshensu can suppress vasoconstriction triggered by norepinephrine and KCl in a dose-dependent manner. |
植物由来 |
別名 | Sodium Danshensu, (±)-DanShenSu sodium salt, (±)-DanShenSu sodium sal |
分子量 | 220.16 |
分子式 | C9H9NaO5 |
CAS No. | 67920-52-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2 mg/mL (9.08 mM)
DMSO: 50 mg/mL (227.11 mM), Heating is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Danshensu sodium salt 67920-52-9 Autophagy Metabolism P450 Sodium Danshensu DanShenSu sodium sal Danshensu (±)-DanShenSu sodium salt inhibit Inhibitor Danshensu sodium (±)-DanShenSu sodium sal inhibitor