Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
100 mg | 在庫あり | ¥ 333,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,000 |
説明 | Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. |
In vitro | Deoxypodophyllotoxin (DPT) induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS).?DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation.?Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability.?Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT.?Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis[1]. |
植物由来 |
分子量 | 398.41 |
分子式 | C22H22O7 |
CAS No. | 19186-35-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (138.05 mM)
You can also refer to dose conversion for different animals. 詳細
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Deoxypodophyllotoxin 19186-35-7 Apoptosis Autophagy Cytoskeletal Signaling Microtubule Associated Microtubule/Tubulin inhibit Inhibitor inhibitor