Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow.
説明 | Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. |
In vitro | Dopexamine, a dopamine analogue, stimulates β-adrenergic as well as dopamine 1 and 2 receptors, offering vasodilatory effects. It effectively mitigates the systemic inflammatory response triggered by endotoxin, including the release of cytokines, the expression of endothelial adhesion molecules, and oxidative stress, without significantly affecting systemic hemodynamics, such as blood pressure or stroke volume. Additionally, dopexamine possesses agonist activity at β2 and dopaminergic receptors, and at dosages that do not impact global hemodynamics or regional microvascular flow, it can diminish tissue leukocyte infiltration and confer protection against organ damage. |
別名 | FPL60278AR |
分子量 | 429.42 |
分子式 | C22H34Cl2N2O2 |
CAS No. | 86484-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (23.29 mM)
You can also refer to dose conversion for different animals. 詳細
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Dopexamine hydrochloride 86484-91-5 GPCR/G Protein Neuroscience Adrenergic Receptor Beta Receptor Dopexamine Inhibitor FPL60278AR Dopexamine Hydrochloride inhibit inhibitor