Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dp44mT, a effective iron chelator, has selective antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 15,000 | |||
50 mg | 在庫あり | ¥ 26,000 | |||
100 mg | 在庫あり | ¥ 45,500 | |||
200 mg | 在庫あり | ¥ 59,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | Dp44mT, a effective iron chelator, has selective antitumor activity. |
In vitro | In MDA-MB-231 cells, Dp44mT selectively targets towards topoisomerase topo2α resulting in DNA damage. Dp44mT inhibits antiproliferative effects significantly with IC50 of 30 nM, 60 nM, and 60 nM for SK-N-MC, SK-Mel-28, and MCF-7 cells, respectively, while showing no effects on normal MRC-5 fibroblasts. In SK-N-MC neuroepithelioma and M109 cells,Dp44mT inhibits cellular Fe uptake from Fe-Tf , and induces cell apoptosis. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). |
In vivo | Dp44mT (0.4 mg/kg, i.v.) inhibits M109 tumor implanted in CD2F1 mice by a dose-dependent manner. |
細胞研究 | SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C. The effect of the chelators on proliferation is examined using the MTT assay. |
動物実験 | CD2F1 mice that are implanted M109 tumors intravenous inject Dp44mT (dissolved in Propylene glycol) 4 mg/kg in twice daily. |
分子量 | 285.37 |
分子式 | C14H15N5S |
CAS No. | 152095-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 57 mg/mL (199.74 mM)
Ethanol: 47 mg/mL (164.69 mM)
H2O: Insoluble
You can also refer to dose conversion for different animals. 詳細
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Dp44mT 152095-12-0 Apoptosis Others Ferroptosis inhibit Dp-44mT Inhibitor inhibitor