Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
説明 | EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity. |
ターゲット&IC50 | ChoKα1:1 μM |
In vitro | EB-3D?exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines and primary cultures of pediatric patients.?Moreover, the drug strongly induces apoptosis and more importantly it enhanced T-leukemia cell sensitivity to chemotherapeutic agents, such as dexamethasone and l-asparaginase.?In addition, the compound induces an early activation of AMPK, the main regulator of cellular energy homeostasis, by its phosphorylation at residue T712 of catalytic subunit α, and thus repressing mTORC1 pathway, as shown by mTOR S2448 dephosphorylation.?The inhibition of mTOR in turn affects the activity of several known downstream targets, such as 4E-BP1, p70S6K, S6 Ribosomal Protein and GSK3 that ultimately may lead to a reduction of protein synthesis and cell death[1]. |
細胞研究 | Cell Line:JURKAT, CCRF-CEM, HSB-2, MOLT-16, DNA-41, LOUCY, PEER, ALL-SIL cells. Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM.Incubation Time:72 hours |
分子量 | 644.4 |
分子式 | C30H36Br2N4O2 |
CAS No. | 1839150-63-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (77.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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EB-3D 1839150-63-8 Apoptosis Chromatin/Epigenetic Neuroscience PI3K/Akt/mTOR signaling AChR AMPK lipid inhibit lymphoblastic AMP-activated protein kinase EB3D acute tumorigenesis homeostasis dephosphorylation Inhibitor EB 3D leukemia HepG2 inhibitor