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Search Results for " dephosphorylation "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

TargetMolキット

カタログ番号	製品名	別名	ターゲット
T7955	EB-3D		Apoptosis , AMPK , AChR
	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.		Apoptosis , AMPK , AChR
TP1015	NFAT Inhibitor	VIVIT peptide	Others
	NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.		Others
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T2208	Bacitracin Zinc	Bacitracin zinc salt,Zinc bacitracin	c-Met/HGFR , Antibacterial , Antibiotic
	Bacitracin Zinc is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, interference for inhibition of cleavage of Tyr from Met-enkephalin(IC50=10 μM).		c-Met/HGFR , Antibacterial , Antibiotic
TP1015L	NFAT Inhibitor acetate	VIVIT peptide acetate,NFAT Inhibitor acetate（249537-73-3 free base）
	NFAT Inhibitor acetate (VIVIT peptide acetate) is a cell-permeable and selective NFAT peptide inhibitor of calmodulin phosphatase-mediated NFAT dephosphorylation.
T10927	Cyt-PTPε Inhibitor-1	Cyt-PTP\|A Inhibitor-1	Phosphatase , Src
	Cyt-PTPε Inhibitor-1 (A Inhibitor-1) is an inhibitor of cytosolic protein tyrosine phosphatase ε. Cyt-PTPε Inhibitor-1 blocks the dephosphorylation of c-Src and exhibits anti-osteoclastic activity.		Phosphatase , Src
T24398	Lenaldekar	LDK	Akt , IGF-1R , S6 Kinase
	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway and delays sensitive cells in late mitosis.		Akt , IGF-1R , S6 Kinase
T16115	MLi-2		LRRK2
	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce...		LRRK2
T71648	CK37
	CK37 controls the biological activity of Choline Kinase-α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
T40507	BTO-1
	BTO-1 is a compound known as a Polo-like kinase (Plk) inhibitor, commonly employed for its effectiveness in regulating processes involving phosphorylation and dephosphorylation.
T40445	Cyclocreatine
	Cyclocreatine, a Creatine analogue, exhibits potent bioenergetic protection by elevating ATP levels. It demonstrates the ability to traverse cell membranes, including the blood-brain barrier, wherein it undergoes phospho...
T77934	PhosTAC7		PROTACs
	PhosTAC7, akin to PROTACs in promoting ternary complex formation, recruits a Ser/Thr phosphatase to a phosphosubstrate to facilitate dephosphorylation.		PROTACs
T28092	MPT0B206
	MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1...
T35937	D-myo-Inositol-1,5,6-triphosphate (sodium salt)
	The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-t...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t...
T69091	CBP501
	CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-spec...
T35806	N-Stearoylsphingosine	C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide	Phosphatase
	N-Stearoylsphingosine is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylati...		Phosphatase
T26456	A 83586C	A83586C,A-83586C
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, wh...
T37040	DiIC1(5)	DiIC1(5)
	DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. It accumulates in mitochondria and its fluorescence intensity decreases when the mitochondrial membrane potenti...
T71217	MPT0B214
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activ...
T35938	D-myo-Inositol-4-phosphate (ammonium salt)
	D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied I...
T60737	LG308
	LG308 shows antimicrotubule activity which is a novel synthetic compound. LG308 induces apoptosis, cell death, and significantly suppresses tumor growth that has the potential for the prostate cancer research. LG308 indu...
T35892	Q134R	Q134R
	Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise fo...

Compounds

EB-3D

T7955

Synonym:

Target: Apoptosis, AMPK, AChR

NFAT Inhibitor

TP1015

Synonym: VIVIT peptide

Target: Apoptosis, AMPK, mTOR

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

Bacitracin Zinc

T2208

Synonym: Bacitracin zinc salt,Zinc bacitracin

Target: c-Met/HGFR, Antibacterial, Antibiotic

NFAT Inhibitor acetate

TP1015L

Synonym: VIVIT peptide acetate,NFAT Inhibitor acetate（249537-73-3 free base）

Target:

Cyt-PTPε Inhibitor-1

T10927

Synonym: Cyt-PTP|A Inhibitor-1

Target: Phosphatase, Src

Lenaldekar

T24398

Synonym: LDK

Target: Akt, IGF-1R, S6 Kinase

D-myo-Inositol-1,5,6-triphosphate (sodium salt)

N-Stearoylsphingosine

T35806

Synonym: C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide

Target: Phosphatase

A 83586C

T26456

Synonym: A83586C,A-83586C

D-myo-Inositol-4-phosphate (ammonium salt)

カタログ番号	製品名	別名	ターゲット
T2185	L-Ascorbic acid 2-phosphate trisodium	L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate	Reactive Oxygen Species , c-Met/HGFR , Endogenous Metabolite
	L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.
T37977	Succinyladenosine
	Succinyladenosine is a biochemical marker of adenylosuccinase (ASL) deficiency. It is formed through the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase [1].
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and ind...
T72100	D-erythro-Sphingosine hydrochloride	Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride
	D-erythro-Sphingosine hydrochloride, also known as Erythrosphingosine, serves as a specific TRPM3 activator and induces retinoblastoma protein dephosphorylation.
TN5639	Rocaglaol	Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio...

天然物製品

L-Ascorbic acid 2-phosphate trisodium

T2185

Synonym: L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate

Target: Reactive Oxygen Species, c-Met/HGFR, Endogenous Metabolite

D-erythro-Sphingosine hydrochloride

T72100

Synonym: Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride

Target:

Rocaglaol

TN5639

Synonym: Ferrugin,Aglaiastatin A

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02398	ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His)	Legionella pneumophila	E. coli
	Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
TMPH-03719	YopH Protein, Yersinia enterocolitica, Recombinant (His & Myc)	Yersinia enterocolitica	E. coli
	Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to...
TMPH-01251	DUSP26 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis...
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot...
TMPH-00266	Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO)	Bovine	E. coli
	Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore th...
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph...
TMPY-02964	Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle...
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro an...
TMPK-00143	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro an...
TMPH-02013	PTPRZ1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligo...
TMPK-00115	CD79B Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal tran...
TMPH-02870	PDXP Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP an...
TMPH-02126	SORBS2 Protein, Human, Recombinant (His)	Human	E. coli
	Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of AB...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His)	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ...
TMPJ-00908	LMW-PTP Protein, Human, Recombinant (His)	Human	E. coli
	Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphat...
TMPY-02197	PPM1G Protein, Human, Recombinant (aa 317-546, His)	Human	E. coli
	Protein phosphatase 1G, also known as Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, Protein phosphatase magnesium-dependent 1 gamma, PP2C-gamma, PPM1G and PPM1C, is a cytoplasm protein that belongs to the...
TMPH-02697	GNA12 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). G...
TMPH-02878	PTPRS Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects...
TMPY-03439	UBASH3A Protein, Human, Recombinant (aa 354-623, His)	Human	E. coli
	UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apopto...
TMPY-02131	Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)	Human	E. coli
	The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of im...
TMPY-02198	ILKAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...