|
T12943 |
SNDX-5613
|
|
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. |
|
T7955 |
EB-3D
|
|
Apoptosis
,
AMPK
,
AChR
|
|
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity. |
|
T8308 |
NL-1
|
|
Mitochondrial Metabolism
,
Autophagy
|
|
NL-1 is a mitoNEET inhibitor with antileukemic effect. |
|
T8003 |
Methotrexate disodium
|
|
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
|
TP1115 |
L-Asparaginase
|
L-ASNase |
Others
|
|
L-Asparaginase (L-ASNase) (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment.Asparaginase is an enzyme that is used as a medication. As a medication, L-a... |
|
T6603 |
Nelarabine
|
GW 506U78,Nelzarabine,506U78 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
|
T16545 |
Pivanex
|
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis
,
HDAC
,
Bcr-Abl
|
|
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T1485 |
Methotrexate
|
NCI-C04671,WR19039,Amethopterin,CL14377 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... |
|
T74710 |
YX-2-107
|
|
CDK
|
|
YX-2-107 is a selective and potent CDK6-degrading PROTAC with an IC50 value of 4.4 nM.YX-2-107 inhibits RB phosphorylation and FOXM1 expression in vitro, and inhibits the development of Ph+ ALL in rats.YX-2-107 can be us... |
|
T72984 |
(Rac)-SHIN2
|
|
Others
|
|
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL). |
|
T76790 |
Inotuzumab
|
|
Others
|
|
Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4 antibody targeting CD22. Inotuzumab is a naked antibody to Inotuzumab ozogamicin and can be used to synthesize antibody-active molecule conjugator... |
|
T1477 |
AICAR
|
NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine) |
Mitophagy
,
YAP
,
AMPK
,
Autophagy
|
|
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. |
|
T21302L |
UNC 569 hydrochloride
|
UNC 569 hydrochloride (1350547-65-7 Free base) |
TAM Receptor
,
TAM Receptor
|
|
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydr... |
|
T36944 |
Ara-G
|
|
Nucleoside Antimetabolite/Analog
|
|
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate... |
|
T31672 |
Erythrofuranosyladenine
|
9-β-D-Erythrofuranosyladenine,ETA |
|
|
Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute l... |
|
T30688 |
Calaspargase pegol
|
|
|
|
Calaspargase pegol is used to treat acute lymphoblastic leukemia. |
|
T24189 |
J9
|
J-9,J 9 |
|
|
J9 is an inhibitor of Glucocorticoid resistance. J9 reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia. |
|
T20858 |
Metanilic acid
|
m-Anilinesulfonic acid,m-Sulfanilic acid |
|
|
Metanilic acid, an anti-cancer drug, is used to treat several malignancies including choriocarcinoma and pediatric acute lymphoblastic leukemia. |
|
T25000 |
Acetylaleuritolic acid
|
NSC 266221,NSC-266221,NSC266221 |
|
|
Acetylaleuritolic acid is a pentacyclic triterpenoid, plant metabolite isolated from the leaves of Garcinia miniata. It has antitumor properties, showing tumor inhibitory activity in tests against P-388 lymphoblastic leu... |
|
T4310L2 |
Prexasertib mesylate
|
LY-2606368,LY2606368,LY 2606368 |
|
|
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a... |
|
T21301 |
Lesinurad sodium
|
Lesinurad,RDEA 594,RDEA-594,RDEA594 |
|
|
UNC569, the first small-molecule MER inhibitor, inhibits Mer activation and downstream signaling through ERK1/2 and AKTwith. UNC569 shows efficacy against acute lymphoblastic leukemia in vitro and in vivo. |
|
T36575 |
HDAC3 Inhibitor
|
|
|
|
HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In add... |
|
T79377 |
NWP-0476
|
|
|
|
NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1]. |
|
T39800 |
S2116
|
|
|
|
S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing recipr... |
|
T76801 |
Denintuzumab
|
|
|
|
Denintuzumab (hBU 12), a recombinant humanized anti-CD19 monoclonal antibody, serves as the antibody component in the synthesis of antibody-drug conjugates (ADC), notably Denintuzumab Mafodotin (SGN-CD19A). This ADC is u... |
|
T76893 |
Lusvertikimab
|
|
|
|
Lusvertikimab (OSE-127), a humanized IL7R monoclonal antibody, does not get internalized by target cells and inhibits IL7R heterodimerization along with subsequent downstream signaling. It demonstrates anti-leukemic prop... |
|
T74994 |
SJ988497
|
|
|
|
SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker... |
|
T78317 |
Blinatumomab
|
Anatumomab |
|
|
Blinatumomab (formerly known as Anatumomab) is a bispecific monoclonal antibody that specifically targets the CD19 antigen on B cells and is utilized in the study of acute lymphoblastic leukemia [1]. |
|
T74538 |
Galectin-3 antagonist 2
|
|
Galectin
|
|
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and demonstrates resistance to pharmaceutical int... |
|
T60361 |
LSD1/2-IN-4
|
|
|
|
LSD1/2-IN-4, a derivative of PCPA, functions as an inhibitor for both lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2), demonstrating K i values of 0.11 μM and 130 μM against LSD1 and LSD2, r... |
|
T39799 |
S2157
|
S2157 |
|
|
S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri... |
|
T35810 |
C24 dihydro Ceramide (d18:0/24:0)
|
Cer(d18:0/24:0) |
|
|
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c... |
|
T79012 |
MDM2/XIAP-IN-2
|
|
|
|
MDM2/XIAP-IN-2 is a dual inhibitor targeting murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). It promotes the degradation of MDM2 and impedes translation of XIAP mRNA, effectively inhibit... |
|
T37068 |
NR-160
|
|
|
|
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a ... |
|
T82259 |
Grisnilimab setaritox
|
WT1-RTA |
|
|
Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA com... |
|
T83930 |
SJ 11646
|
|
|
|
SJ 11646, a potent lymphocyte-specific protein tyrosine kinase (LCK) Degrader (PROTAC) with a DC50 of 0.00838 pM, utilizes Dasatinib as the LCK ligand and incorporates a phenyl glutarimide-based cereblon binder. Demonstr... |
