Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 7,500 | |||
25 mg | 在庫あり | ¥ 11,500 | |||
50 mg | 在庫あり | ¥ 15,000 | |||
100 mg | 在庫あり | ¥ 22,500 | |||
200 mg | 在庫あり | ¥ 42,000 | |||
500 mg | 在庫あり | ¥ 78,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
In vitro | Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. [1] Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain. [2] Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P. [3] Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. [4] |
In vivo | Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. [1] |
別名 | Alesion, Epinastine HCl, WAL-801CL HCl, Elestat |
分子量 | 285.77 |
分子式 | C16H15N3·HCl |
CAS No. | 108929-04-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (174.97 mM)
H2O: 52 mg/mL (182 mM)
Ethanol: 53 mg/mL (185.5 mM)
You can also refer to dose conversion for different animals. 詳細
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Epinastine hydrochloride 108929-04-0 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Histamine Receptor Alesion antiallergic Epinastine HCl WAL-801CL HCl inhibit Epinastine Hydrochloride Epinastine WAL801 WAL 801 insect mast Inhibitor WAL-801 Antihistamine cell vertebrate Elestat neuronal inhibitor