Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 36,500 | |||
2 mg | 在庫あり | ¥ 53,500 | |||
5 mg | 在庫あり | ¥ 91,000 | |||
10 mg | 在庫あり | ¥ 135,000 | |||
25 mg | 在庫あり | ¥ 215,500 | |||
50 mg | 在庫あり | ¥ 289,500 | |||
100 mg | 在庫あり | ¥ 385,500 | |||
500 mg | 在庫あり | ¥ 785,000 |
説明 | Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist. |
In vivo | In moderately overweight and hypercholesterolemic subjects Eprotirome (KB2115) was found to be safe and well tolerated and elicited up to a 40% lowering of total and LDL cholesterol after 14 days of treatment. Bile acid synthesis was stimulated without evidence of increased cholesterol production [1]. KB2115 treated mice exhibited increased fasting glucose, although KB2115 did not increase fasting insulin levels [2]. |
動物実験 | A catheter was implanted into the right internal jugular vein before the hyperinsulinemic-euglycemic clamp. After recovery, mice were administered GC-1 (0.03 or 0.3 mg/kg), KB2115 (0.3 mg/kg) or T3 (0.06 mg/kg) via intraperitoneal injection for 10 days. On the day of the clamp experiment, conscious, overnight-fasted mice received a primed (10 μCi) and constant rate intravenous infusion (0.1 uCi/min) of [3-3H] glucose to measure basal glucose turnover. After 60–75 minutes of labeled glucose infusion, the hyperinsulinemic-euglycemic clamp was performed with continuous infusion of insulin (12 mU/kg/min) and variable infusion of 25% glucose to maintain euglycemia (~120 mg/dl). Blood samples were collected by tail bleeding (approximately every 10 min) to measure blood glucose concentrations [2]. |
別名 | KB2115 |
分子量 | 487.14 |
分子式 | C18H17Br2NO5 |
CAS No. | 355129-15-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30 mg/mL
DMSO: 90 mg/mL (184.75 mM)
You can also refer to dose conversion for different animals. 詳細
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Eprotirome 355129-15-6 Endocrinology/Hormones Thyroid hormone receptor(THR) THR inhibit KB 2115 Inhibitor KB-2115 KB2115 Thyroid Hormone Receptor inhibitor