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阻害剤 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK
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化合物ライブラリー 生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー 天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー ドラッグライク 化合物ライブラリー フラグメントライブラリー カスタム化合物ライブラリー
シグナル伝達経路 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル
DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー
天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー
ドラッグライク 化合物ライブラリー ドラッグライクライブラリー
フラグメントライブラリー ゼネラルフラグメントライブラリー 特徴的なフラグメントライブラリー カスタム化合物ライブラリー
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

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Search Results for " proteasome-mediated "

ターゲット

Apoptosis Ligand for E3 Ligase Molecular Glues

12

阻害剤

2

天然化合物

14

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T10765 Eragidomide CC-90009,Cereblon modulator 1 Apoptosis , Ligand for E3 Ligase , Molecular Glues
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
T11600 IBR2 Isoquinoline DNA/RNA Synthesis
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA...
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T12818 S119-8 Influenza Virus
RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting gen...
T29024 TX2-121-1 TX 21211,TX 2-121-1
TX2-121-1 targets HER3 for proteasome-mediated degradation to inhibit HER3-dependent signalling and growth.
T70902 AQ-101
AQ-101 is a inhibitor of MDM2, which induces MDM2 protein degradation through a self-ubiquitination and proteasome-mediated mechanism.
T16354 NSC745885 Others
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cel...
T39975 MS33 MS33
MS33 is a highly effective degrader of the WDR5 protein, exhibiting Kd values of 870 nM and 120 nM for VCB and WDR5, respectively. It induces degradation of WDR5 through an E3 ligase VHL-mediated and proteasome-dependent...
T77939 WBC100 14-D-Valine-TPL c-Myc
WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway, primarily utilized in research for c-Myc overexpressing tu...
T74508 SS47
SS47, a PROTAC -based HPK1 degrader , exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the?in?vivo?antitumor efficacy of BCMA CAR-T cell research. HPK1, an?immunos...
T74336 YF135
YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhi...
T79718 CaMKIIα-PHOTAC CaMK
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule facilitates the ubiquitination and subsequent proteasome-medi...
カタログ番号 製品名 別名 ターゲット
T2S1837 Steviol NSC 226902,Hydroxydehydrostevic acid Others
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...
T79941 Antimycin A2c Apoptosis
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces cas...

天然物製品

Steviol
T2S1837
Synonym: NSC 226902,Hydroxydehydrostevic acid
Target: Others
Antimycin A2c
T79941
Synonym:
Target: Apoptosis

Recombinant Proteins

Species：
Human (10)
Mouse (3)
HIV-2 (1)
Expression System：
E. coli (8)
Baculovirus-Insect Cells (3)
Baculovirus Insect Cells (2)
P. pastoris (Yeast) (1)
Tag：
N-terminal 6xHis-tagged (3)
N-10xHis (2)
N-6xHis (2)
C-6xHis (1)
GST (1)
His,GST,AVI (1)
N-His (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-SUMO-tagged (1)
Tag Free (1)
カタログ番号 製品名 Species Expression System
TMPY-02101 KEAP1 Protein, Human, Recombinant (His & GST & Avi) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432 KEAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPH-02630 MDM2 Protein, Mouse, Recombinant (His) Mouse E. coli
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ...
TMPH-01269 SMURF2 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPH-01522 HIV-2 (subtype A, isolate ROD) Protein Vpx (His) HIV-2 P. pastoris (Yeast)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-02282 Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Human E. coli
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPY-04389 MAP3K8 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPH-01270 TRAIP Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPJ-01100 UBE2V1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPH-02633 TRIM21 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02632 TRIM21 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-01073 CD81 Protein, Human, Recombinant (His & SUMO) Human E. coli
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati...
TMPH-01531 IKBKB Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPH-01532 IKBKB Protein, Human, Recombinant (E. coli, His) Human E. coli
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
カタログ番号 製品名
L3800 NF-κB Signaling Compound Library

729 compounds
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;

ライブラリー

NF-κB Signaling Compound Library
L3800
Compounds: 729
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