Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 37,500 | |||
25 mg | 在庫あり | ¥ 74,000 | |||
50 mg | 在庫あり | ¥ 114,000 | |||
100 mg | 在庫あり | ¥ 166,000 |
説明 | Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2]. |
ターゲット&IC50 | Aminopeptidase A:200 Nm(ki) |
In vivo | Oral administration of QGC-001(0.1-30 mg/kg; p.o.) crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats[2]. |
別名 | QGC 001, QGC-001, RB-150, RB150, QGC001, RB 150 |
分子量 | 368.51 |
分子式 | C8H20N2O6S4 |
CAS No. | 648927-86-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL (81.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Firibastat 648927-86-0 Metabolism Aminopeptidase hypertensive inhibit Inhibitor angiotensin pressure QGC 001 QGC-001 brain RB-150 blood RB150 QGC001 RB 150 inhibitor