|
T10511 |
Anti-hypertensive sulfonanilide 1
|
|
Others
|
|
Anti-hypertensive sulfonanilide 1 is an antihypertensive compound. |
|
T3474 |
RO 46-8443
|
|
Endothelin Receptor
|
|
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. |
|
T0993 |
Methoxamine hydrochloride
|
Methoxamine HCl |
Adrenergic Receptor
|
|
Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. |
|
T22398 |
Phenidone
|
1-phenyl-3-pyrazolidinone |
Lipoxygenase
,
COX
|
|
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg... |
|
T28482 |
Firibastat
|
QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 |
Aminopeptidase
|
|
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively... |
|
T5329 |
Trandolapril
|
|
Angiotensin-converting Enzyme (ACE)
|
|
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. |
|
T0287 |
Hexamethonium Bromide
|
Gangliostat,Simpatoblock,Hexamethonium Dibromide |
Apoptosis
,
Dopamine Receptor
,
AChR
|
|
Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. |
|
T22236 |
Alprenolol hydrochloride
|
|
5-HT Receptor
|
|
Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. |
|
T4560 |
Alprenolol
|
Alpheprol,(RS)-Alprenolol,dl-Alprenolol |
5-HT Receptor
,
Adrenergic Receptor
|
|
Alprenolol (Alpheprol) is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
|
T3046 |
BMY 7378 dihydrochloride
|
BMY7378 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor. |
|
T9097 |
Guanadrel
|
|
Others
|
|
Guanadrel is an antihypertensive agent. |
|
T1615 |
Irbesartan
|
SR-47436,BMS-186295 |
Apoptosis
,
RAAS
|
|
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. |
|
T23044 |
N,N'-Dicyclohexylurea
|
DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 |
Epoxide Hydrolase
|
|
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. |
|
T6835 |
Fenoldopam mesylate
|
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526 |
Dopamine Receptor
|
|
Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
|
T80661 |
Antihypertensive sulfonanilide XVII
|
|
Others
|
|
Antihypertensive sulfonanilide XVII is an orally available antihypertensive sulfonanilide small molecule compound for the study of hypertension. |
|
T79267 |
Antihypertensive agent 3
|
|
|
|
Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs) [1]. |
|
T79266 |
Antihypertensive agent 2
|
|
|
|
Antihypertensive agent 2 (Compound 4g) exhibits effective antagonistic activities against angiotensin II receptor 1 and reduces blood pressure with equal or greater potency than Losartan [1]. |
|
T16329 |
Nitroflurbiprofen
|
NO-flurbiprofen,Nitroxybutyl flurbiprofen,HCT 1206 |
COX
|
|
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. |
|
T17111 |
Todralazine hydrochloride
|
Ecarazine hydrochloride |
Adrenergic Receptor
|
|
Todralazine hydrochloride (Ecarazine hydrochloride) is a β2AR blocker and has antioxidant and free radical scavenging activities. Todralazine hydrochloride can be used in anti-hypertensive research. |
|
T14942 |
CGP48369
|
|
RAAS
|
|
CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats. |
|
T10595 |
BQ-788
|
BQ788 |
Endothelin Receptor
|
|
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press... |
|
T2528 |
Latanoprost
|
Xalatan,PHXA41 |
GPR
,
Prostaglandin Receptor
,
RAR/RXR
|
|
Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. |
|
T36506 |
Tempone
|
4-Oxo-tempo |
|
|
Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats. |
|
T0126 |
Diazoxide
|
SRG-95213,Sch-6783,Proglycem |
ATPase
,
Potassium Channel
,
Autophagy
|
|
Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. |
|
T24932 |
Vatanidipine
|
AE-0047,AE 0047,AE0047 |
Calcium Channel
|
|
Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi... |
|
T37496L |
Alamandine TFA
|
|
RAAS
|
|
Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-h... |
|
T1275 |
Phentolamine mesylate
|
Phentolamine methanesulfonate,Phentolamine mesilate |
Adrenergic Receptor
|
|
Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS... |
|
T20570 |
Labetalol
|
Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne |
Adrenergic Receptor
|
|
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... |
|
T21416 |
Hydroflumethiazide
|
Diurometon,Glomerulin,Diuredemina,Flutizide,Hidroflumetiazid |
|
|
Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive. |
|
T24478 |
MK-8141
|
MK 8141,ACT 077825,ACT077825,ACT-077825 |
|
|
MK-8141 is a renin inhibitor. It displays some antihypertensive efficacy in hypertensive patients. |
|
T27743 |
KRH-594 free acid
|
WK14922K,WK-1492,WK-14922K,WK1492 |
|
|
KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-pron... |
|
T13328 |
AE0047 Hydrochloride
|
|
Calcium Channel
|
|
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease. |
|
T17112 |
Todralazine
|
Ecarazine |
Others
|
|
Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity. |
|
T31598 |
Ecadotril
|
S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049 |
|
|
Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role. |
|
T71396 |
FCE-24379
|
|
|
|
FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats. |
|
T34945 |
Trimazosin hydrochloride
|
CP19106-1,CP 19106-1,Trimazosin HCl,CP-19106-1 |
|
|
Trimazosin hydrochloride is used in the treatment of hypertensive patients failing to respond to thiazides. |
|
T40688 |
Fulvine
|
|
|
|
Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo. |
|
T26802 |
BIBS-222
|
BIBS 222 |
|
|
BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. |
|
T15680 |
L-159282
|
MK 996 |
Others
|
|
L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity. |
|
T28039 |
Milfasartan
|
LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081 |
|
|
Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats. |
|
T81681 |
Neuromedin U-25 (porcine)
|
|
|
|
Neuromedin U-25 (porcine) is a peptide known for its uterotonic and hypertensive properties [1]. |
|
T38424 |
(R)-Fadrozole
|
FAD286,(R)-CGS 16949A free base,(R)-Fadrozole |
|
|
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp... |
|
T71065 |
Quinapril-d5
|
|
|
|
Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapr... |
|
T11642 |
Imidaprilate
|
Imidaprilat,6366A |
RAAS
|
|
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM). It is used in the research of the hypertensive disease. |
|
T27306 |
Fasidotril
|
BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137 |
|
|
Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in pati... |
|
T78063 |
Endothelin-1 (1-31) (Human) TFA
|
|
ERK
|
|
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1]. |
|
T14672 |
BMS-248360
|
|
Others
|
|
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hype... |
|
TP1892 |
γ1-MSH
|
|
|
|
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exh... |
|
TP2126 |
R 892
|
|
|
|
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (AC... |
|
TP2096 |
ELA-21 (human)
|
|
|
|
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh... |
