|
T83972 |
NOX-6-18
|
GPR132 antagonist 1,GPR132-B-160 |
GPR
|
|
NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain. |
|
T73718 |
MDCG sodium
|
NOX 100 sodium,N-methyl-N-dithiocarboxyglucamine sodium |
Endogenous Metabolite
|
|
MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd. |
|
T33716 |
Norathiol
|
NOX-100,NOX100,NOX 100 |
Endogenous Metabolite
|
|
Norathiol (N-methyl-N-dithiocarboxyglucamine) is an antidote for cadmium poisoning and a metal chelator that promotes the excretion of 109Cd and can be used in the treatment of cadmium poisoning. |
|
T4359 |
VAS2870
|
|
NADPH
|
|
VAS2870 is an inhibitor of NADPH oxidase (NOX). |
|
T8107 |
GLX351322
|
|
NADPH-oxidase
,
NADPH
|
|
GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM. |
|
T15433 |
GSK2795039
|
|
Apoptosis
,
Reactive Oxygen Species
,
ROS
,
NADPH
|
|
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays). |
|
T68796 |
Thr101
|
|
|
|
Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor. |
|
T22990 |
ML-090
|
Fluoflavine |
NADPH-oxidase
,
Others
|
|
ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM). |
|
T6099 |
Setanaxib
|
GKT137831 |
NADPH-oxidase
,
Ferroptosis
,
NADPH
|
|
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor. |
|
T7191 |
Diphenyleneiodonium chloride
|
DPI |
NOS
,
Reactive Oxygen Species
,
NADPH
,
TRP/TRPV Channel
|
|
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. |
|
T8408 |
GKT136901
|
AK120765 |
NADPH-oxidase
,
NADPH
|
|
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite |
|
T10353 |
APX-115 free base
|
Ewha-18278 free base |
NADPH-oxidase
,
NADPH
|
|
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid... |
|
T25944 |
Phenoxyacetone
|
NSC-1876,NSC 1876,NSC1876 |
Others
|
|
Phenoxyacetone (NSC-1876) is an inhibitor of acetylcholinesterase. |
|
T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
|
Compound W |
Gamma-secretase
|
|
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). |
|
T3263 |
(6R,7S)-Cefminox sodium heptahydrate
|
Meicelin,Cefminox Sodium,Alteporina,Tencef |
Antibiotic
|
|
(6R,7S)-Cefminox sodium heptahydrate (Meicelin) is a broad-spectrum, bactericidal cephalosporin antibiotic. It is especially effective against Gram-negative and anaerobic bacteria. |
|
T7804 |
Garenoxacin mesylate hydrate
|
Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) |
Antibacterial
|
|
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains. |
|
T50115 |
3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride
|
|
Others
|
|
3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride is a synthetic compound belonging to the class of azabicyclooctanes. It is a potent and selective agonist of the dopamine D2 receptor and is widely used to study the mech... |
|
T20824 |
Cyanox CY 1790
|
Lowinox 1790,Irganox 3790,Antioxidant 1790,Irganox-3790,DN 90 |
Others
|
|
Cyanox CY 1790 (Irganox-3790) is an agent with antioxidant activity. |
|
T7843 |
4-phenoxypiperidine
|
|
Others
|
|
4-phenoxypiperidines with muscle relaxant and anticonvulsant activities. |
|
TP1886L1 |
NoxA1ds acetate(1435893-78-9 free base)
|
|
NADPH-oxidase
|
|
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col... |
|
T22424 |
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
|
|
Apoptosis
,
STAT
|
|
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular ca... |
|
T7153 |
Vanoxerine dihydrochloride
|
GBR-12909 dihydrochloride,I893 dihydrochloride |
Dopamine Receptor
|
|
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM) |
|
T27417L |
Glutathione arsenoxide hydrochloride
|
GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base) |
Apoptosis
,
AChR
|
|
Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) is a potentially active anti-cancer molecule and inhibitor of tumour metabolism. glutathione arsenoxide hydrochloride ta... |
|
T33479 |
Monoxerutin
|
Z 12007,MonoHER,7-Monohydroxyethylrutosid |
Antioxidant
|
|
Monoxerutin (MonoHER) is a vasodilator with antioxidant activity that prevents adriamycin-induced cardiotoxicity in mice and is used in the study of acute respiratory syndrome. |
|
T0451 |
Minoxidil
|
U10858 |
Potassium Channel
,
COX
|
|
Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. |
|
T2222 |
Carbinoxamine Maleate Salt
|
Lergefin,CarbinoxaMine Maleate |
Histamine Receptor
|
|
Carbinoxamine Maleate Salt (Lergefin) is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. |
|
T1190 |
Cefmenoxime hydrochloride
|
Cefmenoxime hemihydrochloride,SCE-1365 hemihydrochloride |
Antibacterial
,
Antibiotic
,
Antifection
|
|
Cefmenoxime hydrochloride (Cefmenoxime hemihydrochloride) is a cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganis... |
|
T1639 |
Amlexanox
|
CHX3673,Amoxanox,AA673 |
IL Receptor
,
FGFR
,
Others
,
IκB/IKK
|
|
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan... |
|
T66390 |
4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide
|
|
|
|
4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide is an aromatic enigma that is is a metabolite of the antitumor drug rafenil. |
|
T0992 |
Carbenoxolone disodium
|
Biogastrone,Duogastrone,Bioral |
Gap Junction Protein
|
|
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ... |
|
T7564 |
Chlorphenoxamine
|
Contristamine |
Histamine Receptor
|
|
Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. |
|
T16961 |
Supinoxin
|
RX-5902 |
Apoptosis
,
DNA/RNA Synthesis
|
|
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50... |
|
T8321 |
10-methyl-9-(phenoxycarbonyl) Acridinium
|
|
Others
|
|
10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions |
|
T5200 |
Indirubin-3'-monoxime
|
Indirubin-3'-oxime |
GSK-3
,
Lipoxygenase
,
CDK
|
|
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). |
|
T9872 |
Acetic acid, 2-[4-[(2-ethyl-3-benzofuranyl)carbonyl]phenoxy]-
|
|
Others
|
|
Acetic acid, 2-[4-[(2-ethyl-3-benzofuranyl)carbonyl]phenoxy]- is a compound used for antiviral activity determinations. |
|
T68166 |
Traxanox
|
|
Others
|
|
Traxanox is an orally available diuretic.Traxanox enhances phagocytosis of yeast granules by mouse peritoneal macrophages or rat peritoneal polymorphonuclear leukocytes in vitro.Restorative effect of Traxanox on inhibiti... |
|
T19633 |
Ionox 330
|
Antioxidant 40,BRN 2034522,Ahydol,Antioxidant 330,AO-40 |
Others
|
|
Ionox 330 (Ahydol) is an alkylphenol compound used as an antioxidant. |
|
T20076 |
Irganox 1010
|
Dovernox 10 |
Others
|
|
Irganox 1010 (Dovernox 10) is an agent of antioxidant. |
|
T1177 |
Sulfaquinoxaline
|
Avicocid,Sulphaquinoxaline,Sulfabenzpyrazine |
Others
,
Antibacterial
,
Antibiotic
,
Parasite
|
|
Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent. |
|
T1158 |
Phenoxybenzamine hydrochloride
|
NCI-c01661,NSC 37448,Phenoxybenzamine HCl |
CaMK
,
Adrenergic Receptor
|
|
Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non... |
|
T7902 |
Ozenoxacin
|
T-3912 |
Antibacterial
|
|
Ozenoxacin (T-3912) is a quinolone antibacterial. It shows potent activities against the main microorganisms isolated from soft tissue and skin infections. |
|
T0717 |
Enoxacin hydrate
|
CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate |
DNA gyrase
,
DNA/RNA Synthesis
,
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
|
T1586 |
Tenoxicam
|
Ro-12-0068,Tenoxicamum,Mobiflex,Tilcotil |
COX
|
|
Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain. |
|
T20293 |
Phenoxyethanol
|
NSC 1864,NSC-1864,NSC1864 |
Others
,
Antibacterial
|
|
Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds. |
|
T0274 |
Cinoxacin
|
Compound 64716 |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid. |
|
T8135 |
Minoxidil sulfate
|
Minoxidil sulphate,U-58838 |
Potassium Channel
|
|
Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. |
|
T0717L |
Enoxacin
|
NSC 629661,AT 2266,Pd107779,CI 919 |
DNA/RNA Synthesis
,
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. |
|
T3431 |
Pardoprunox hydrochloride
|
SLV-308 hydrochloride,DU-126891 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept... |
|
T0917 |
Sulfaquinoxaline sodium salt
|
SQ-Na,Sulfaquinoxaline sodium |
Antibacterial
,
Antibiotic
,
Parasite
|
|
Sulfaquinoxaline sodium salt (SQ-Na) is a veterinary broad-spectrum antimicrobial agent with antigram-negative and gram-positive activity.Sulfaquinoxaline can be used to prevent coccidiosis and bacterial infections. |
|
T50072 |
3-amino-1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one dihydrochloride
|
|
Others
|
|
3-amino-1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one dihydrochloride is used in the synthesis of various compounds. |
