Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 65,000 | |||
25 mg | 在庫あり | ¥ 112,500 | |||
50 mg | 在庫あり | ¥ 149,500 | |||
100 mg | 在庫あり | ¥ 213,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 41,000 |
説明 | Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM). |
ターゲット&IC50 | JAK1:73 nM |
In vitro | AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM). |
In vivo | AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells. |
別名 | AZD4205 |
分子量 | 489.57 |
分子式 | C25H31N9O2 |
CAS No. | 2091134-68-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (510.65 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Golidocitinib 2091134-68-6 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK AZD-4205 Janus kinase AZD 4205 Inhibitor inhibit AZD4205 inhibitor