store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM).
説明 | Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM). |
ターゲット&IC50 | CK2:0.74 μM |
In vitro | Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Hematein (50 and 100 μM; 48 hours) causes apoptosis in A427 lung cancer cells. Hematein (10-100 μM; 14 days) inhibits cell growth in A427 lung cancer cells [1]. |
In vivo | In A427 lung cancer cell xenografts, Hematein (i.p.; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth [1]. |
別名 | Hydroxybrasilein |
分子量 | 300.26 |
分子式 | C16H12O6 |
CAS No. | 475-25-2 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.5 mg/mL (18.32 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Hematein 475-25-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin Akt Hydroxybrasilein Inhibitor inhibitor inhibit