Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 19,500 | |||
10 mg | 在庫あり | ¥ 29,000 | |||
25 mg | 在庫あり | ¥ 47,500 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 126,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor. |
ターゲット&IC50 | Wnt (SW480 cells):19.5 nM (EC50) |
In vivo | Adavivint (SM04690) is a?novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee. |
動物実験 | A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model. |
別名 | Adavivint (SM04690) |
分子量 | 505.55 |
分子式 | C29H24FN7O |
CAS No. | 1467093-03-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Adavivint 1467093-03-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin Wnt Adavivint (SM04690) Lorecivivint SM 04690 inhibit Inhibitor SM04690 SM-04690 inhibitor