Powder: -20°C for 3 years | In solvent: -80°C for 1 year
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells.
説明 | I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells. |
ターゲット&IC50 | PI5P4Kα:1 µM |
In vitro |
I-OMe Tyrhost AG 538 (0-3 µM; 1 hour) can prevent the phosphorylation of Akt, IGF-1R, and Erk.[1] I-OMe Tyrphostin AG 538 (0.1-1000 µM; 24 hours) has cytotoxicity on PANC-1 cells in nutrient deficient culture medium.[1] |
別名 | I-OMe-AG 538 |
分子量 | 437.19 |
分子式 | C17H12INO5 |
CAS No. | 1094048-77-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (102.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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I-OMe-Tyrphostin AG 538 1094048-77-7 PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors IGF-1R PI3K I-OMe-Tyrphostin AG-538 I-OMe-AG538 I-OMe-AG 538 I-OMe-AG-538 I-OMe-Tyrphostin AG538 Inhibitor inhibitor inhibit