Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 75,500 | |||
50 mg | 在庫あり | ¥ 112,500 | |||
100 mg | 在庫あり | ¥ 164,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 21,500 |
説明 | IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). |
ターゲット&IC50 | HIF1α:3.65 μM |
In vitro | IDF-11774 treatment suppressed angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduced glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreased the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells. |
In vivo | Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. |
動物実験 | When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model. |
分子量 | 368.51 |
分子式 | C23H32N2O2 |
CAS No. | 1429054-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (162.82 mM)
You can also refer to dose conversion for different animals. 詳細
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IDF-11774 1429054-28-3 Angiogenesis Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF inhibit HIF-PH IDF 11774 Hypoxia-inducible factors HIFs IDF11774 Inhibitor inhibitor