Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
説明 | E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
In vitro | E3330 affects hemangioblast development in vitro via inhibition of Ape1 redox activity. [1] E3330 inhibits the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibits the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. [2] In JHH6 cells, E3330 prevents the functional activation of NF-κB via the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage of the redox-mediated activation of NF-κB. [3] |
In vivo | In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuates the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. [4] In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine. [5] |
細胞研究 | PANC1 cells are placed in one well of a 12-well plate and treated with 5 to 30 μM E3330. After a 24, 48, and 72 h of culture, the cells are washed with PBS and stained with trypan blue, and cell viability is examined by counting the live cell numbers.(Only for Reference) |
分子量 | 378.46 |
分子式 | C21H30O6 |
CAS No. | 136164-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL (185 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 70 mg/mL (185 mM)
You can also refer to dose conversion for different animals. 詳細
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E3330 136164-66-4 Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism DNA/RNA Synthesis HIF/HIF Prolyl-Hydroxylase pancreatic cancer TNF-α REF-1 NF-κB HIFs Inhibitor HIF-PH Nuclear factor-kappaB APX-3330 APE1 APX 3330 NSCLC cells neuroprotective APX3330 E-3330 endonuclease VEGFR EPCs AP-1 HUVECs Nuclear factor-κB Reactive Oxygen Species E 3330 DNA-binding Activator Protein 1 Hypoxia-inducible factors orally PANC1 anticancer H1975 PCECs inhibit IL-8 Vascular endothelial growth factor receptor inhibitor