Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM.
説明 | K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM. |
ターゲット&IC50 | ACAT1:0.45 μM, ACAT2:102.85 μM |
In vitro | a novel ACAT inhibitor, K-604. The IC(50) values of K-604 for human ACAT-1 and ACAT-2 were 0.45 and 102.85 micromol/L, respectively, indicating that K-604 is 229-fold more selective for ACAT-1. Kinetic analysis indicated that the inhibition was competitive with respect to oleoyl-coenzyme A with a K(i) value of 0.378 micromol/L. Exposure of human monocyte-derived macrophages to K-604 inhibited cholesterol esterification with IC(50) of 68.0 nmol/L. Furthermore, cholesterol efflux from THP-1 macrophages to HDL(3) or apolipoprotein A-I was enhanced by K-604[1]. |
分子量 | 575.64 |
分子式 | C23H32Cl2N6OS3 |
CAS No. | 217094-32-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (108.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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K-604 dihydrochloride 217094-32-1 Metabolism Acyltransferase K604 dihydrochloride acyl-CoA:cholesterol acyltransferase K-604 inhibit Inhibitor Diacylglycerol acyltransferase K604 K 604 Dihydrochloride K 604 Diglyceride acyltransferase mono- acylglycerol acyltransferase K-604 Dihydrochloride K604 Dihydrochloride K 604 dihydrochloride inhibitor