Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multiple membrane trafficking steps.
説明 | PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multiple membrane trafficking steps. |
ターゲット&IC50 | Golgi-associated LPAT:15 μM, ACAT:73 nM |
In vitro | In the chronic cholesterol-fed rat model, CI 976 decreases non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol in rats with pre-established dyslipidemia[4]. |
別名 | CI 976 |
分子量 | 393.56 |
分子式 | C23H39NO4 |
CAS No. | 114289-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/ml(63.52 mM)
DMF: 25 mg/ml(63.52 mM)
Ethanol: 25 mg/ml(63.52 mM)
You can also refer to dose conversion for different animals. 詳細
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PD 128042 114289-47-3 Metabolism Acyltransferase CI 976 inhibit oral CI-976 Diacylglycerol acyltransferase transferase secretory PD128042 LPAT PD-128042 acyl-CoA:cholesterol acyltransferase mono- acylglycerol acyltransferase endocytic membrane trafficking pathway ACAT CI976 Diglyceride acyltransferase Inhibitor inhibitor